In mixing bowl, combine 1 1/2 cups of flour, yeast, oregano and garlic powder.
In saucepan, heat water, butter, sugar and salt just until water is warm, stirring to melt butter. Add to dry ingredients mixture in mixing bowl. Beat at low speed for 1/2 minute, scraping sides of bowl constantly. Beat at high speed for 3 minutes.
By hand, stir in pepperoni and enough remaining flour to make a moderately soft dough.
Cover, let rise in warm place until double, 45 to 60 minutes.
Stir dough down. Spread evenly in greased 9 x 5 x 3-inch pan. Let rise until double, about 30 minutes.
Bake in 375 degree F oven for 35 to 40 minutes. Remove from pan: cool on rack.
Makes 1 loaf.